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Severe Gastrointestinal Disease: Individuals with severe stomach or gut problems, like gastroparesis (slow stomach emptying), should not use semaglutide

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Many candidates also experience persistent cravings, insulin resistance, or metabolic slowing that GLP-1 therapy may help address

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Quick Answer: Weight gain on Ozempic can occur due to compensatory eating patterns, reduced physical activity from gastrointestinal side effects, concurrent medications, or improved glycaemic control reducing glucose loss in urine