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A possible explanation for the null effect on performance and/or adaptation may be that the CM dose was too low, as this was significantly reduced compared to the dose typically used to produce ergogenic effects (2 g vs 8 g)

doi: 10.1089/105072501300176462 28 Rodriguez-DiazEPearceEN

Therefore, an increased supply of Met may increase antioxidant production, potentially aiding in the relief of oxidative stress and inflammation triggered by the production of reactive oxygen metabolites ( Conversely, Hcy has the capacity for remethylation to regenerate methionine, which relies on the folate cycle and vitamin B 12 ( Figure 1 ) ( 2 -THF), which is subsequently reduced to 5-methyltetrahydrofolate (5-CH 3 -THF) (Preynat et al., 2009)

After absorption, ergothioneine circulates in the blood and accumulates in target tissues via OCTN1 transporters

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