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Although diabetes incidence showed only a modest increase in all mice, the study found a significant acceleration of T1D onset in females and an increase in insulitis in males (114)

Arch Biochem Biophys 1983, 223: 381-392

Stick to the 3 to 3.7 liter range unless you exercise intensely or live in a hot climate, and spread intake evenly throughout the day rather than drinking large volumes at once, which can trigger nausea in a tirzepatide-slowed stomach

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