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In healthy individuals, the incretin effect stimulates insulin secretion, accounting for about 70% of total insulin secretion, with GIP contributing two-thirds of this effect, which is higher than that of GLP-1

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Additionally, it was reported that trimetazidine (TMZ), a piperazine derivative, mediated activation of the GSH system and had antioxidant and cytoprotective effects in several myocardial injury models [210,211,212,213]