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In certain embodiments, a responder may be considered as a subject for which treatment as described herein provides equal to or more than about 2 points, or about 1 standard deviation, in the VABS-II composite scores

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For satisfaction signals, it directly acts on the peripheral tissues and central nervous system (CNS) and is therefore known as the satiety hormone. The obese (ob) gene encodes leptin, which is released by adipose tissue