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Our experience working with research teams across metabolic studies confirms this pattern: protocols that administer IGF-1 LR3 during insulin-resistant periods (late evening, within two hours post-meal) consistently show attenuated downstream signaling markers compared to fasted or pre-workout administration

Community guidance for those on metformin or berberine suggests a lower MOTS-c dose with closer glucose monitoring in the first weeks consult a clinician

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