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Beyond deacetylation of histone proteins, HDACs also accept non-histone proteins as their substrates, finally affecting physiological and disease-related cellular processes, such as transcriptional machinery, DNA damage, signal transduction, protein folding, autophagy, and metabolism [60]

10.1021/acsnano.0c03080 Summary Keywords glutathione exhaustion, reduction-response, metal nanomaterials, TME regulation, cancer therapy Citation Liu P, Hao L, Liu M and Hu S (2023) Glutathione-responsive and -exhausting metal nanomedicines for robust synergistic cancer therapy