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In a 2023 review, inositol supplementation was described as an effective and safe treatment in PCOS, with outcomes comparable to metformin in some cases.5 L-Methylfolate (500mcg): Folate has been shown to positively affect glycemic, inflammatory, and oxidative stress markers in women with PCOS.7 It may also support fertility and reproductive outcomes, particularly when combined with other nutrients.67 Wholesome Story uses L-methylfolate (MTHF), the biologically active form of folate, which does not require conversion in the body and is often chosen in reproductive-health formulations.86 Vitamin D3 (1,000 IU): One additional consideration is dosing flexibility

For CROs and local drug development programs, models that reproducibly accelerate DKD progression offer practical advantages in timeline, cost, and translational predictability

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Curr Diabetes Rev (2017) 13:5829

Maintenance phase: Take 3-5 g per day, ideally after training or with a recovery drink (protein shake or sports drink)