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Thus, glutathionylation of IDE with GSNO and GSNO(ox) treatment was explored using an anti-glutathione antibody (Figure 5)

Toxic substances in cigarette smoke have the potential to increase free radicals, malondialdehyde (MDA) levels and to decrease endogenous antioxidant (glutathione/GSH) levels

Also, the study has some limitations, such as the fact that the researchers only used aged female mice for their experiments

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Behensky AA, Yasny IE, Shuster AM, Seredenin SB, Petrov AV, Cuevas J