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Eastern Asia, Eastern Europe, and parts of Central and South America are highly affected by this cancer, whereas most regions in Africa, North America, and Northern Europe have lower relative rates of GC [147, 148]

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IGFBP3 has also been identified as a gene target of FOXA1 and has been shown to be involved in the regulation of cell proliferation in prostate cancer cells (Imamura et al., 2012)