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Quick Comparison | Feature | Rybelsus | Ozempic | | --- | --- | --- | | Active ingredient | Semaglutide | Semaglutide | | Form | Oral tablet (daily) | Subcutaneous injection (weekly) | | Doses available | 3 mg, 7 mg, 14 mg | 0.25 mg, 0.5 mg, 1 mg, 2 mg | | Bioavailability | ~1% (most is broken down in stomach) | ~89% | | Monthly cost | $250-$350 | $250-$340 | | Approved for | Type 2 diabetes | Type 2 diabetes | | Dosing requirements | Empty stomach, 30 min before food/water | Any time, no food restrictions | How Rybelsus Works Rybelsus is semaglutide formulated with a special absorption enhancer called SNAC (sodium N-[8-(2-hydroxybenzoyl) amino] caprylate)