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Drug: Nitroglycerin- is typically taken sublingually (buccal cavity) where it enters the circulation and is rapidly delivered directly to the heart (without having to go through the liver first), thus avoiding the First Pass Effect

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The pharmacophore is the chemical structure itself

Thus, in addition to skeletal muscle, it includes visceral organs, body fluids, connective tissues, and other components

Circadian adaptations to meal timing: neuroendocrine mechanisms