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While these products may improve access for some individuals, they also introduce important clinical, regulatory, and medicolegal challenges

The 4.5 mg dose produced 10.8% mean weight loss at 26 weeks

In hemochromatosis (a model of systemic iron overload), erythrocytes display increased PS exposure, elevated calpain activity (a cysteine protease mediating cytoskeletal degradation during eryptosis), and reduced deformabilitychanges that enhance splenic macrophage clearance (du Plooy et al., 2018

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