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In 2024, semaglutide 2.4 mg (Wegovy) received FDA approval for cardiovascular risk reduction in adults with established cardiovascular disease and either overweight or obesity, based on the SELECT trial

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It downregulates the gene and protein expression of COX1, 5-LOX, 12-LOX, and 15-LOX in the arachidonic acid pathway, restores the levels of abnormal metabolites such as PGE2, PGD2, LTB4, 12-HETE, 15-HETE, PGF2, and 8-iso-PGF2 in PAH models, inhibits abnormal proliferation of PASMCs, and reverses pulmonary vascular remodeling (Song et al., 2022)

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