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Besides the increase in melanin content, AL lesions are characterized by epidermal alterations such as proliferation/differentiation disbalance or mitochondrial dysfunction, dermal photoaging marks, and disorganization of the dermal extracellular matrix (ECM) [21,22,23]. In particular, AL lesions present an impairment of the cutaneous structure with a marked elongation of the dermalepidermal junction (DEJ), an accumulation of melanin in the epidermis, especially in the rete ridges [21]

Cells 12 , 500 (2023)

tCr levels were significantly higher in controls compared to migraine with aura (t(34.8) = 3.27, p = 0.007)

Formation of hydrogen peroxide Hydrogen peroxide (H2O2) is one of the ROS formed by mitochondria during aerobic respiration

It also helps regenerate other antioxidants, like Vitamin C and Vitamin E, so they can keep working in your system