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PGC-1 coactiva mltiples factores de transcripcin incluyendo los receptores activados por proliferadores de peroxisomas, particularmente PPAR que regula genes de la beta-oxidacin, los factores respiratorios nucleares NRF-1 y NRF-2 que regulan genes de la cadena de transporte de electrones, y el receptor relacionado con estrgeno ERR

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