Drug Class and Mechanism of Action Semaglutide and Tirzepatide belong to different drug classes
The medication itself is FDA-approved, just not for that particular purpose
Brain Volume and Vessels Presentation Proportional with the Change of the Brain or Vessels Surface Area The presentation of the brain, and peripheral veins (azygos, superior mesenteric and inferior caval) was recorded in deeply anaesthetized rats, with a camera attached to a VMS-004 Discovery Deluxe USB microscope (Veho, USA), before procedure in normal, and then, in rats with ligated superior sagittal sinus 15 min after procedure, before and after therapy as well as at the 15 min, 24 h and 48 h ligation-time before sacrifice
Derek Lowe, writing on science.org, summarized the conundrum eloquently
We therefore used female animals in our study