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Based on the findings, GLP-1 medications may benefit the cardiovascular and renal systems while also promoting weight loss, glycemic management, neurocognition, gut function, liver inflammation, alcohol use, and suicidal ideation

Southern Medical Journal

PPARa contributes to neuronal ferroptosis by regulating the FSP1-CoQ10-NAD(P)H pathway through its transcriptional activity To elucidate the specific mechanism by which PPARa regulates FSP1, we constructed stable cell lines with either over-expression or knockdown of PPARa using lentiviral vectors

Loss of muscle mass : Up to 2025% of weight lost on GLP-1s may come from muscle rather than fat

Effects of rhaponticin on retinal oxidative stress and inflammation in diabetes through NRF2/HO-1/NF-B signalling