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However, the most significant weight reduction typically occurs after the patient reaches higher therapeutic doses (5.0 mg or above) over several months of consistent use

Neuherbs' 90-day clinical trial on Indian adults at Currex Good Life Hospital, Bangalore, found triglycerides dropped by up to 26%, total cholesterol by 31%, and the inflammation marker hsCRP by 37%, all without adverse effects

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In terms of the anorectic pathways in the brain, the anorectic effects of MC4R agonism are mediated by downstream responses of POMC/CART neurons [26, 27]