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46 In patients with T2DM, the Tirzepatide versus Semaglutide once weekly in patients with T2DM (SURPASS-2) trial compared tirzepatide with semaglutide 1 mg (both as add-on therapies to metformin) and found tirzepatide was either noninferior or superior at all doses (5 mg, 10 mg 15 mg), for both HbA 1c reduction and weight loss at 40 weeks

FDA panel, with ties to the peptide industry, recommends easing restrictions on four of the compounds A Food and Drug Administration advisory committee narrowly voted in favor of loosening restrictions on peptides over strong objections from agency career scientists

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Relative mRNA expression was calculated using the 2 Ct method