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The combination of a RAAS inhibitor with a steroidal MRA (spironolactone or eplerenone) may not be suitable, despite steroidal MRAs demonstrating efficacy in conditions such as HFrEF, resistant hypertension [58,59,60,61], hyperaldosteronism (spironolactone), as well as reducing proteinuria/albuminuria [60,61,62,63]

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Systemic actions: They are both found in several tissues, as well as in circulation, where they modulate metabolism, oxidative stress, cell survival, and inflammation

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