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Although old age is associated with increased utilization of APAP, mouse studies did not find increased hepatotoxicity after acute, chronic, and sub-acute APAP exposure in old mice [172]

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This range is comfortable for subcutaneous injection, and the volume is large enough that small measurement errors don't create significant dose variability

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Prior findings have demonstrated that vascular and atrial endothelial dysfunction was associated with AF via a number of different mechanisms, including the alterations in hemodynamics parameters and endothelial cell shear stress, aggravating oxidative stress, exacerbating proinflammatory agents, and down-regulation of NOS expression and NO* production in atrial endocardium