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Those are potentially two phenotypes

2024;387:e080340

Understanding Diabetes and Mental Health

Genetic screening of mtDNA mutations follows the criteria defined by DiMauro and Schon, 71 considering the presence of neutral polymorphisms, evolutionarily conserved and phenotypically distinct mutations, deletion mutations exhibiting heteroplasmy, and how the degree of heteroplasmy aligns with the severity of symptoms

The whole elegance of KPV is that PepT1, its transporter, is enriched in the intestinal epithelium and induced further in inflamed gut which is precisely why oral delivery targets the peptide to inflamed bowel so neatly