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At the agent-level, several individual GLP-1RAs demonstrated moderate to high certainty for MACE when compared with placebo, whereas certainty for other outcomes was generally low to moderate, reflecting wider confidence intervals and greater between-study heterogeneity (Supplementary Table S26)

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Institutions like UAB are helping the world understand how these medications work on biological, neurological, and metabolic levels

Two other GLP-1 agonists, Ozempic and Wegovy, from Novo Nordisk, are in high demand in the U.S