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Glucagon-like peptide 1 and glucose-dependent insulinotropic peptide receptor agonists protect synaptic plasticity in animal models of Alzheimers disease The previous section showed that GLP-1 and GIP signaling has direct effects on synaptic transmission and LTP in the hippocampus

Following the case report mentioned above, the safety profile of GLP1-RAs in patients with SLE has been questioned

Another study in aging rats found that epitalon increased the activities of the antioxidant enzymes superoxide dismutase, glutathione peroxidase, and glutathione-S-transferase

Furthermore, AMPK boosts glucose absorption in insulin-responsive tissues such as adipocytes, muscle cells, and hepatocytes, proving effective in enhancing glucose uptake in vitro (Zhang et al., 2009

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