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found that Erchen decoction can reduce the fat content in mice fed a high-fat diet by increasing peroxisome proliferator-activated receptor (PPAR) and lipoprotein lipase (LPL) (Zhang et al., 2020)

Comprehensive programs incorporating: Nutritional counseling emphasizing gradual caloric reduction (500750 kcal/day deficit) Regular physical activity (150 minutes weekly moderate-intensity exercise) Behavioral therapy and support groups Slower weight loss targets (0.51 kg or 12 pounds weekly) This approach minimizes gallstone formation risk through gradual weight reduction while still achieving meaningful health benefits

This shift likely represents an adaptive response to chronic excitatory activity and the metabolic burden imposed by recurrent seizures, as previously proposed in models of refractory epilepsy 16

You can consider other FDA-approved medications like phentermine, orlistat, and SGLT-2 inhibitors

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