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[DOI] [PMC free article] [PubMed] [Google Scholar] 159.Bruegger JJ, Smith BC, Wynia-Smith SL, Marletta MA
329,330 In degenerative joint diseases like OA, the metabolic balance of chondrocytes is disrupted, leading to the overproduction of degrading enzymes and inflammatory mediators, including iNOS, MMP-13, and ADAMTS5 (a disintegrin and metalloproteinase with thrombospondin motifs 5), which participate in cartilage degradation and inflammatory processes
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Low erythrocyte levels of GPX and GR among patients indicate that superoxides formed by antioxidants of various thiol-containing compounds (glutathione) result in decreased levels of GR
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