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According to preliminary results, ferroptosis may be involved in balancing the synovium growth and death

One ligand was subjected to the legumain-catalyzed hydrolysis when exposed to its 1,2-thiolamino groups, whereas second ligand containing cyano group would react immediately with the 1,2-thiolamino groups via click cycloaddition forming the AuNPs aggregates

This 2:1 ratio ensures there is plenty of Vitamin C available to support the recycling of the glutathione molecules

These agents include thiazolidinediones (PPAR- agonists), dipeptidyl peptidase-4 (DPP-4) inhibitors, sulfonylureas, sodium-glucose co-transporter 2 (SGLT2) inhibitors, -glucosidase inhibitors, and glucagon-like peptide-1 (GLP-1) receptor agonists