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The loading-then-maintenance approach comes from TB-500 protocols you hit it hard initially to get cells migrating, then taper to a maintenance frequency

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Neamati S, Lirezaei M, Kheradmand A et al (2013) Antioxidant enzyme activities assay and thiobarbituric acid reactive substances concentration following administration of ghrelin in the rat kidney

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It is an important tri-peptide that contains cysteine, glutamic acid, and glycine