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460 The biosynthesis of NAD + in adipocytes is crucial for the extension of HDF-induced white fat depots and may have more specific effects in lipid accumulation and processing

Researchers started describing it as a genome reset, because the pattern in aged cells shifted back toward what youd expect from younger tissue (PMID: 25815981)

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Despite these limitations, irisin exemplifies a broader class of exercise-responsive peptides whose endocrine effects are context-dependent and may be poorly captured by static circulating measurements