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Beyond its antioxidant role, Thioctic Acid also enhances cellular metabolism and helps regulate blood sugar

They represent the next generation of obesity therapeutics and several may become available within the next 12-24 months

Obesity, insulin resistance and fatty liver may further amplify this cycle by increasing inflammatory signaling, altering bile-acid metabolism and reducing metabolic reserve

Others just need monitoring

68 However, in a population using GLP-1 RAs for obesity management without history of diabetes, increased risk of pancreatitis associated with the GLP-1 RAs was found compared to bupropion-naltrexone (HR 9.1, 95%CI 1.2566.0) suggesting the risk benefit ratio of these medications is influenced by underlying disease state