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To overcome these limitations, this review discusses a range of structural modifications, including N-terminal and C-terminal substitutions, fatty acid conjugation, and large molecule fusion technologies, which have collectively contributed to enhanced half-life, increased stability, improved receptor affinity, and retained or augmented bioactivity of GLP-1 analogs

Matthiesen, M

By influencing these pathways simultaneously, Mounjaro offers a powerful approach to reducing calorie intake and promoting sustainable weight loss

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Hyperglycemia triggers various pathological mechanisms that lead to excessive ROS, including H 2 O 2 , in diabetic wounds [8]