glp-1 agonists muscle loss receptor agonists, which are effective for weight loss, can cause substantial loss. A Comment in @TheLancetEndo discusses the effects of GLP-1 receptor on skeletal muscle mass: https://t.co/qQ85u86B1G What Are GLP-1 Agonists For

At the receptor level, IGF-1 LR3 binds the IGF-1 receptor (IGF1R) and activates its intrinsic tyrosine kinase domain, which initiates downstream signaling through the PI3K/AKT and MAPK/ERK cascades

Eur J Cancer (2021) 145:21020

2022;212(Pt C):113348

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