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COMBINING GLP-1 AND ESTROGEN LEADS TO SYNERGISTIC EFFECT ON WEIGHT LOSS, GLYCEMIC CONTROL, AND FOOD REWARD Hypothalamic GLP-1R expression increases during late proestrus, when estrogen levels are high GLP-1 secretion from pancreas or intestinal cells is increased in direct action of estrogen in these cells

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The UK SmPC advises that if patients experience gastrointestinal symptoms, delaying dose increases or reducing to a previous dose should be considered until symptoms improve

A tiny cannula is placed under the skin through a surgical incision to gently suction out fatty deposits