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In addition to impaired EEC signaling and gut peptide release, GF models have impaired ENS activation compared with conventionalized and specific-pathogen-free models 245,246

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As spotlighted in Februarys Nature Reviews Drug Discovery, in which Lees myostatin discovery and ensuing investigations over the next three decades are featured, there are clinical trials of at least 10 drugs either underway or soon launching that target myostatin and the related protein activin A or their receptors in varied ways or with a combination of drugs, with even more clinical trials rapidly evolving