The FDA doesnt regulate dietary supplements for safety or effectiveness before they hit the market, whether theyre a daily multivitamin or a post-workout protein powder
[DOI] [PubMed] [Google Scholar] 13.Newsome P.N., Buchholtz K., Cusi K., Linder M., Okanoue T., Ratziu V., Sanyal A.J., Sejling A.S., Harrison S.A., NN9931-4296 Investigators A placebo-controlled trial of subcutaneous semaglutide in nonalcoholic steatohepatitis
What I didnt know until I started my rabbit hole was that GLP-1 receptors are found on immune cell types like T cells, B cells, macrophages, eosinophils, and on mast cells themselves
The 12mg-cohort escalation consumes 2 + 2 + 2 + 2 + 4 + 4 + 4 + 4 + 8 + 8 + 8 + 8 + 10 + 10 + 10 + 10 = 96 mg over 16 weeks before reaching peak maintenance dose, meaning two 30mg vials cover the full escalation period, and subsequent maintenance can be planned around a 30mg-vial cadence (2.5 weeks of supply per vial at 12mg/week)
It is not free money