On average, semaglutide GLP-1 injections achieve a 15% reduction in starting weight when used as part of a comprehensive weight loss plan
There is no additional benefit wearing the patch longer than 8 hours
Kessler documents his experience in the new book Diet, Drugs, and Dopamine: The New Science of Achieving a Healthy Weight
What we prioritize first Before focusing on GLP-1 dosing terminology, we prioritize the clinical fundamentals that have the strongest relevance to cognitive longevity: blood pressure optimization ApoB, LDL, triglyceride, and lipoprotein(a) risk assessment insulin resistance and glucose-pattern evaluation visceral fat and body-composition measurement resistance training and aerobic fitness sleep quality and sleep apnea evaluation when appropriate hearing and vision support nutrition quality and protein adequacy alcohol moderation inflammation and immune-metabolic context hormone evaluation when clinically indicated social connection, cognitive engagement, and meaningful activity None of these interventions is glamorous by itself
Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes