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Precursor overload occurs when patients with Huntington's disease or Alzheimer's disease have an excessive intake amount of choline

Case Example A 42-year-old woman with MTHFR C677T homozygous (TT) presented with elevated homocysteine (18 mol/L), hypertension, and family history of stroke

It cannot be legally prescribed, sold over the counter, or introduced into interstate commerce as a dietary ingredient

(The University of Western Ontario, PhD thesis, 2018)

These findings suggest that VD alleviates NAFLD-associated inflammation primarily through the upstream regulation of cellular stress and senescence processes, rather than through direct modulation of the inflammatory cytokine network