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In obese pre-adolescents with hyperinsulinemia, metformin reduced BMI, BMI SDS, weight, HOMA-IR, fasting insulin, and fasting glucose (122)

72 Bone loss is influenced by initial body weight, age, sex, physical activity, extent of energy restriction and protein intake, and rate of weight reduction, with older individuals and females experiencing greater bone loss

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Second, the patient should meet established criteria for pharmacologic weight management intervention, such as BMI 30 kg/m or BMI 27 kg/m with weight-related comorbidities, consistent with FDA indications

Retatrutide may help reduce appetite and support weight loss, but healthy eating habits and regular physical activity are still important for achieving and maintaining the best results