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[4] [5] The GLP-1 component works by stimulating insulin secretion in a glucose-dependent manner, suppressing glucagon release, and reducing appetite through central nervous system pathways

But that makes the access problem not just a financial issue, but a public health crisis

Initial efforts to reduce -cell mass via partial pancreatectomy resulted in PBH recurrence in a substantial fraction of patients 135 , suggesting that islet function rather than mass drives surgery-induced insulin secretion 136

P., Kumar, H., Lausvig, N

GLP-1/GIP chimeric peptides capable of activating both receptors have shown remarkable weight-losing and glucose-lowering efficacy in obese individuals with T2D