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Possible Side Effects and Complications Both tirzepatide and semaglutide can cause side effects, especially in the early stages of treatment
In humans, neuroimaging studies show associative evidence that GLP-1 agonists alter brain responses to food cues, potentially dampening the neural reactivity to appetizing foods that may trigger binge episodes in susceptible individuals
Although GLP-1 released from the gut may interact with local GLP-1R+ sensory nerve fibres communicating signals to the parabrachial nucleus that enable meal termination [85], the importance of these circuits for long-term control of body weight has not been established
They may progress through multiple stages of involution with an eventual return to normal-appearing skin
The strict empty-stomach routine, with only a small sip of water and a wait before eating, maximizes the small amount that does get absorbed food and other liquids in the stomach interfere with it
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