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Most patients report reduced appetite and smaller portion sizes within the first few weeks, which gradually translates into measurable weight reduction

MOTS-c is widely referenced in metabolic and aging research literature for its characterized role in cellular stress response, AMPK pathway activation, and glucose and lipid metabolism regulation in experimental models

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The sensitivity analysis (individuals with BMI 30 kg/m 2 ) generally reinforced findings from the BMI 27 kg/m 2 population, with both GLP-1 RAs demonstrating consistent associations with better ocular outcomes compared to traditional anti-obesity medications (Fig