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Klebanoff: Even with lower negotiated prices, prior authorization may block access to GLP-1s for both obesity and diabetes, even for patients who are clinically eligible for treatment

Wegovy (semaglutide) does not significantly affect cytochrome P450 enzymes, so clinically relevant pharmacokinetic interactions with common anti-seizure medications are not expected

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Eight to twelve weeks of treatment at 100200 mg kg 1 day 1 lowers plasma leptin and MCP-1 while restoring adiponectin when normalized to fat mass [63]