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Semaglutide Explained Semaglutide is a synthetic peptide that mimics the action of the naturally occurring hormone glucagon-like peptide-1 (GLP-1)

[DOI] [PubMed] [Google Scholar] 80.Ilic S., Drmic D., Zarkovic K., Kolenc D., Brcic L., Radic B., Djuzel V., Blagaic A.B., Romic Z., Dzidic S., et al

However, weight regain averages 25-30% of lost weight within 12 months after discontinuation, because the underlying hunger and metabolic dysfunction return

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Multiple meta-analyses in obesity medicine journals confirm that sustained medication use produces superior long-term outcomes compared to time-limited or tapered approaches