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Yes, coffee can interfere with oral semaglutide absorption if consumed too soon after taking the medication

FDA-approved medications have undergone extensive testing to ensure their safety and efficacy, providing a level of assurance that may not exist with compounded versions

doi:10.1073/pnas.1513973112 Underhill SM et al (2020): Amphetamine Stimulates Endocytosis of the Norepinephrine and Neuronal Glutamate Transporters in Cultured Locus Coeruleus Neurons