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This potential restoration of p53s function by the FOXO4-DRI peptide might enable it to trigger the programmed cell death of senescent cells, essentially clearing out cells that might otherwise contribute to the decline in tissue function seen in aged cell cultures

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These include: Nausea Vomiting Diarrhea Constipation Bloating and abdominal discomfort Gastrointestinal Tolerability and Dose Escalation For both tirzepatide and retatrutide, gastrointestinal symptoms are most pronounced during the initial initiation phase and immediately following a dose escalation step