Even though safety questions still surround is compounded tirzepatide, the drug itself is usually well tolerated when prescribed and applied appropriately under the supervision of a healthcare professional
For instance, a study on ME/CFS demonstrated the efficacy of the tricarboxylic acid (TCA) cycle metabolite oxaloacetate in improving symptoms (Cash and Kaufman, 2023), patients showed marked improvements in fatigue scores as measured by the Chalder Fatigue Questionnaire in a randomized, double-blind, placebo-controlled trial using AXA1125
Secondly, efficacy is the core criterion for evaluating drugs, and currently, multi-target GLP-1 drugs have shown better efficacy
Psoriasis (Auckl)
| Take home message A study presented at the European Congress on Obesity showed that semaglutide (Ozempic/Wegovy) could reduce the number of major cardiovascular events (MACE), like a heart attack or stroke, by 20% compared to placebo (participants not taking the medication)