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Indirect Bile Acid Signaling to the CNS via the FXR-FGF 15/19 Pathway In addition to their direct actions within the CNS, bile acids exert indirect effects on brain function through enterohepatic endocrine signaling pathways

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Intrathecal administration Invasive drug administration by injection through the skull or the spine, allowing the drug to reach the cerebrospinal fluid, and thus the brain, without crossing the bloodbrain barrier

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In short the hormones increase production of insulin and decrease release of glucagon which in turn lowers blood glucose