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Shaking the vial, squirting the water directly onto the powder, or otherwise handling the solution roughly can destroy the very compound you're trying to study

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Referral to endocrinology, cardiology, or lipid specialists may be warranted for complex cases involving multiple cardiovascular risk factors, familial hypercholesterolemia, severe hypertriglyceridemia (500 mg/dL), or inadequate response to initial therapy

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Delivering large molecules through skin is inherently difficult