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The defining distinction is receptor coverage: Semaglutide: Single-pathway agonist GLP-1 only Tirzepatide: Dual-pathway agonist GLP-1 + GIP Retatrutide: Triple-pathway agonist GLP-1 + GIP + glucagon The addition of glucagon receptor activity is the variable most commonly studied in models examining energy expenditure and hepatic lipid behaviour, which has positioned retatrutide as the focal compound in current metabolic peptide literature

The broader market for weight-loss therapies is entering a new acceleration phase

Afterwards, the dosage is escalated by 0.1 mg every 4 weeks, when needed

According to the company, this typically happens within 24 hours

Clinical trial data strongly suggests retatrutide produces significantly greater weight loss